Ontology highlight
ABSTRACT:
SUBMITTER: Antonova-Koch Y
PROVIDER: S-EPMC6516198 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Antonova-Koch Yevgeniya Y Meister Stephan S Abraham Matthew M Luth Madeline R MR Ottilie Sabine S Lukens Amanda K AK Sakata-Kato Tomoyo T Vanaerschot Manu M Owen Edward E Jado Juan Carlos JC Maher Steven P SP Calla Jaeson J Plouffe David D Zhong Yang Y Chen Kaisheng K Chaumeau Victor V Conway Amy J AJ McNamara Case W CW Ibanez Maureen M Gagaring Kerstin K Serrano Fernando Neria FN Eribez Korina K Taggard Cullin McLean CM Cheung Andrea L AL Lincoln Christie C Ambachew Biniam B Rouillier Melanie M Siegel Dionicio D Nosten François F Kyle Dennis E DE Gamo Francisco-Javier FJ Zhou Yingyao Y Llinás Manuel M Fidock David A DA Wirth Dyann F DF Burrows Jeremy J Campo Brice B Winzeler Elizabeth A EA
Science (New York, N.Y.) 20181201 6419
To discover leads for next-generation chemoprotective antimalarial drugs, we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing <i>Plasmodium</i> spp. parasites (681 compounds showed a half-maximal inhibitory concentration of less than 1 micromolar). Cluster analysis identified potent and previously unreported scaffold families as well as other series previously associated with chemoprophylaxis. Further testing through multiple phenot ...[more]