Ontology highlight
ABSTRACT:
SUBMITTER: Roddie HG
PROVIDER: S-EPMC6516643 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Roddie Hannah Grace HG Armitage Emma Louise EL Coates Jonathon Alexis JA Johnston Simon Andrew SA Evans Iwan Robert IR
PLoS biology 20190514 5
Macrophages encounter and clear apoptotic cells during normal development and homeostasis, including at numerous sites of pathology. Clearance of apoptotic cells has been intensively studied, but the effects of macrophage-apoptotic cell interactions on macrophage behaviour are poorly understood. Using Drosophila embryos, we have exploited the ease of manipulating cell death and apoptotic cell clearance in this model to identify that the loss of the apoptotic cell clearance receptor Six-microns-u ...[more]