Elusive Conformational Dynamics of PPAR? Inactivation Tied Down by Chemical Cross-Linking.
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ABSTRACT:
SUBMITTER: Mohr JP
PROVIDER: S-EPMC6516750 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Elusive Conformational Dynamics of PPARγ Inactivation Tied Down by Chemical Cross-Linking.
Mohr Jared P JP Bruce James E JE
Structure (London, England : 1993) 20181101 11
In this issue of Structure, Zheng et al. (2018) have described the dynamics of PPARγ in complex with a non-agonist by exploring its solution-phase conformational landscape through chemical cross-linking in combination with a multitude of different treatment conditions, including their new synthetic anti-diabetic non-agonist, revealing the physical mechanism of PPARγ inactivation. ...[more]
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