Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC6516833 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Wang Qian Q Lepus Christin M CM Raghu Harini H Reber Laurent L LL Tsai Mindy M MM Wong Heidi H HH von Kaeppler Ericka E Lingampalli Nithya N Bloom Michelle S MS Hu Nick N Elliott Eileen E EE Oliviero Francesca F Punzi Leonardo L Giori Nicholas J NJ Goodman Stuart B SB Chu Constance R CR Sokolove Jeremy J Fukuoka Yoshihiro Y Schwartz Lawrence B LB Galli Stephen J SJ Robinson William H WH
eLife 20190514
Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence suggests that dysregulated innate immunity is likely involved. Here, we performed proteomic, transcriptomic, and electron microscopic analyses to demonstrate that mast cells are aberrantly activated in human and murine osteoarthritic joint tissues. Using genetic models of mast cell deficiency, we demonstrate that lack of mast cells attenuates osteoarthritis in mice. Using genetic and pharmacologic approaches, ...[more]