Chirality Dependence of Amyloid β Cellular Uptake and a New Mechanistic Perspective.

ABSTRACT: Amyloid β is an inherently disordered peptide that can form diverse neurotoxic aggregates, and its 42-amino-acid isoform is believed to be the agent responsible for Alzheimer's disease (AD). Cellular uptake of the peptide is a pivotal step for it to be able to exert many of its toxic actions. The cellular uptake process is complex, and numerous competing internalization pathways have been proposed. To date, it remains unclear which of the uptake mechanisms are particularly important for the overall process, and improvement of this understanding is needed, so that better molecular AD therapeutics can be designed. Chirality can be used as a unique tool to study this process, because some of the proposed mechanisms are expected to proceed in stereoselective fashion, whereas others are not. To

SUBMITTER: Dutta S 

PROVIDER: S-EPMC6517241 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature