Ontology highlight
ABSTRACT:
SUBMITTER: Mercurio S
PROVIDER: S-EPMC6517317 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Mercurio Sara S Serra Linda L Motta Alessia A Gesuita Lorenzo L Sanchez-Arrones Luisa L Inverardi Francesca F Foglio Benedetta B Barone Cristiana C Kaimakis Polynikis P Martynoga Ben B Ottolenghi Sergio S Studer Michèle M Guillemot Francois F Frassoni Carolina C Bovolenta Paola P Nicolis Silvia K SK
iScience 20190426
Visual system development involves the formation of neuronal projections connecting the retina to the thalamic dorso-lateral geniculate nucleus (dLGN) and the thalamus to the visual cerebral cortex. Patients carrying mutations in the SOX2 transcription factor gene present severe visual defects, thought to be linked to SOX2 functions in the retina. We show that Sox2 is strongly expressed in mouse postmitotic thalamic projection neurons. Cre-mediated deletion of Sox2 in these neurons causes reduct ...[more]