Bedtime doses of prazosin do not affect daytime salivary amylase markers in PTSD.
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ABSTRACT:
SUBMITTER: McCall WV
PROVIDER: S-EPMC6517516 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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Bedtime doses of prazosin do not affect daytime salivary amylase markers in PTSD.
McCall William Vaughn WV Pillai Anilkumar A Pandya Chirayu D CD McCloud Laryssa L Moraczewski Jason A JA Tauhidul Liniya L Youssef Nagy A NA Case Doug D Rosenquist Peter B PB
Heliyon 20190511 5
Overactivity of the noradrenergic (NE) system within the central nervous system (CNS) has been postulated as a key pathophysiology of posttraumatic stress disorder (PTSD). The activity of the enzyme salivary α-amylase (sAA) has been proposed as an indirect measure of CNS NE activity, and sAA is elevated in PTSD. As an antagonist of the α-1 NE receptor, prazosin would be expected to alter sAA values in PTSD patients. However, given its short half-life, it is not clear whether bedtime doses would ...[more]
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