Unknown

Dataset Information

0

Genome-wide association study of right-sided colonic diverticulosis in a Korean population.


ABSTRACT: Diverticulosis results from complex interactions related to aging, environmental factors and genetic predisposition. Despite epidemiologic evidence of genetic risk factors, there has been no attempt to identify genes that confer susceptibility to colonic diverticulosis. We performed the first genome-wide association study (GWAS) on susceptibility to diverticulosis in a Korean population. A GWAS was carried out in 7,948 healthy individuals: 893 patients and 1,075 controls comprised the test set, and 346 patients and 305 controls comprised the replication set. Diverticulosis was diagnosed by colonoscopy during comprehensive medical check-ups, and single-nucleotide polymorphisms (SNPs) related to diverticulosis were detected with the Affymetrix Axiom KORV1.1-96 Array. In all, 9 SNPs were identified in three SNP aggregates in the test set (P?

SUBMITTER: Choe EK 

PROVIDER: S-EPMC6517584 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Genome-wide association study of right-sided colonic diverticulosis in a Korean population.

Choe Eun Kyung EK   Lee Jong-Eun JE   Chung Su Jin SJ   Yang Sun Young SY   Kim Young Sun YS   Shin Eun-Soon ES   Choi Seung Ho SH   Bae Jung Ho JH  

Scientific reports 20190514 1


Diverticulosis results from complex interactions related to aging, environmental factors and genetic predisposition. Despite epidemiologic evidence of genetic risk factors, there has been no attempt to identify genes that confer susceptibility to colonic diverticulosis. We performed the first genome-wide association study (GWAS) on susceptibility to diverticulosis in a Korean population. A GWAS was carried out in 7,948 healthy individuals: 893 patients and 1,075 controls comprised the test set,  ...[more]

Similar Datasets

| S-EPMC7034899 | biostudies-literature
| S-EPMC6842072 | biostudies-literature
| S-EPMC2928134 | biostudies-literature
| S-EPMC4196376 | biostudies-literature
| S-EPMC10040618 | biostudies-literature
| S-EPMC3306582 | biostudies-literature
| S-EPMC6804985 | biostudies-literature
| S-EPMC10452379 | biostudies-literature
| S-EPMC2795935 | biostudies-literature
2019-06-01 | GSE83397 | GEO