The heritable basis of gene-environment interactions in cardiometabolic traits.

ABSTRACT:

Aims/hypothesis

Little is known about the heritable basis of gene-environment interactions in humans. We therefore screened multiple cardiometabolic traits to assess the probability that they are influenced by genotype-environment interactions.

Methods

Fourteen established environmental risk exposures and 11 cardiometabolic traits were analysed in the VIKING study, a cohort of 16,430 Swedish adults from 1682 extended pedigrees with available detailed genealogical, phenotypic and demographic information, using a maximum likelihood variance decomposition method in Sequential Oligogenic Linkage Analysis Routines software.

Results

All cardiometabolic traits had statistically significant heritability estimates, with narrow-sense heritabilities (h ²) ranging from

SUBMITTER: Poveda A 

PROVIDER: S-EPMC6518092 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature