Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels.
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ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC6518791 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels.
Wu Zheng Z Huo Qingwei Q Ren Liang L Dong Fengping F Feng Mengyang M Wang Yue Y Bai Yuting Y Lüscher Bernhard B Li Sheng-Tian ST Wang Guan-Lei GL Long Cheng C Wang Yun Y Wu Gangyi G Chen Gong G
Molecular brain 20190515 1
Neonatal seizures are different from adult seizures, and many antiepileptic drugs that are effective in adults often fail to treat neonates. Here, we report that gluconate inhibits neonatal seizure by inhibiting CLC-3 chloride channels. We detect a voltage-dependent outward rectifying Cl<sup>-</sup> current mediated by CLC-3 Cl<sup>-</sup> channels in early developing brains but not adult mouse brains. Blocking CLC-3 Cl<sup>-</sup> channels by gluconate inhibits seizure activity both in neonatal ...[more]
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