Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Gago P
PROVIDER: S-EPMC6518939 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Martín-Gago Pablo P Olsen Christian A CA
Angewandte Chemie (International ed. in English) 20181026 4
Selective covalent modification of a targeted protein is a powerful tool in chemical biology and drug discovery, with applications ranging from identification and characterization of proteins and their functions to the development of targeted covalent inhibitors. Most covalent ligands contain an affinity motif and an electrophilic warhead that reacts with a nucleophilic residue of the targeted protein. Because the electrophilic warhead is prone to react and modify off-target nucleophiles, its re ...[more]