Unknown

Dataset Information

0

Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis.


ABSTRACT: Collective behaviour in mixed populations of synthetic protocells is an unexplored area of bottom-up synthetic biology. The dynamics of a model protocell community is exploited to modulate the function and higher-order behaviour of mixed populations of bioinorganic protocells in response to a process of artificial phagocytosis. Enzyme-loaded silica colloidosomes are spontaneously engulfed by magnetic Pickering emulsion (MPE) droplets containing complementary enzyme substrates to initiate a range of processes within the host/guest protocells. Specifically, catalase, lipase, or alkaline phosphatase-filled colloidosomes are used to trigger phagocytosis-induced buoyancy, membrane reconstruction, or hydrogelation, respectively, within the MPE droplets. The results highlight the potential for exploiting surface-contact interactions between different membrane-bounded droplets to transfer and co-locate discrete chemical packages (artificial organelles) in communities of synthetic protocells.

SUBMITTER: Rodriguez-Arco L 

PROVIDER: S-EPMC6519160 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis.

Rodríguez-Arco Laura L   Kumar B V V S Pavan BVVSP   Li Mei M   Patil Avinash J AJ   Mann Stephen S  

Angewandte Chemie (International ed. in English) 20190402 19


Collective behaviour in mixed populations of synthetic protocells is an unexplored area of bottom-up synthetic biology. The dynamics of a model protocell community is exploited to modulate the function and higher-order behaviour of mixed populations of bioinorganic protocells in response to a process of artificial phagocytosis. Enzyme-loaded silica colloidosomes are spontaneously engulfed by magnetic Pickering emulsion (MPE) droplets containing complementary enzyme substrates to initiate a range  ...[more]

Similar Datasets

| S-EPMC4814833 | biostudies-other
| S-EPMC5072289 | biostudies-literature
| S-EPMC3530389 | biostudies-literature
| S-EPMC5965539 | biostudies-literature
| S-EPMC5983919 | biostudies-literature
| S-EPMC5552811 | biostudies-literature
2009-12-14 | GSE14074 | GEO
| S-EPMC2669828 | biostudies-other
| S-EPMC7336866 | biostudies-literature
| S-EPMC6195185 | biostudies-literature