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?-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.

ABSTRACT:

Background

The objective of this study was to investigate the discriminating value of a range of CSF ?-synuclein species for dementia with Lewy bodies compared with Alzheimer's disease, PD, and cognitively normal controls.

Methods

We applied our recently published enzyme-linked immunosorbent assays to measure the CSF levels of total ?-synuclein, oligomeric ?-synuclein, and phosphorylated ?-synuclein in dementia with Lewy bodies (n?=?42), Alzheimer's disease (n?=?39), PD (n?=?46), and controls (n?=?78). General linear models corrected for age and sex were performed to assess differences in ?-synuclein levels between groups. We used backward-elimination logistic regression analysis to investigate the combined discriminating value of the different CSF ?-synuclein species and Alzheimer's disease biomarkers.

Results

CSF levels of total ?-synuclein were lower in dementia with Lewy bodies and PD compared with Alzheimer's disease as well as controls (P??0.40, P?1-42 . The optimal combination to differentiate dementia with Lewy bodies from controls consisted of amyloid-?_1-42 , tau, total ?-synuclein, oligomeric ?-synuclein, age, and sex (AUC, 0.90). To differentiate dementia with Lewy bodies from Alzheimer's disease, the combination of tau and oligomeric ?-synuclein resulted in an AUC of 0.83. CSF ?-synuclein species do not contribute to the differentiation of dementia with Lewy bodies from PD.

Conclusions

CSF ?-synuclein species could be useful as part of a biomarker panel for dementia with Lewy bodies. Evaluating both oligomeric ?-synuclein and total ?-synuclein in CSF helps in the diagnosis of dementia with Lewy bodies. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

SUBMITTER: van Steenoven I

PROVIDER: S-EPMC6519232 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.

van Steenoven Inger I Majbour Nour K NK Vaikath Nishant N NN Berendse Henk W HW van der Flier Wiesje M WM van de Berg Wilma D J WDJ Teunissen Charlotte E CE Lemstra Afina W AW El-Agnaf Omar M A OMA

Movement disorders : official journal of the Movement Disorder Society 20181115 11

<h4>Background</h4>The objective of this study was to investigate the discriminating value of a range of CSF α-synuclein species for dementia with Lewy bodies compared with Alzheimer's disease, PD, and cognitively normal controls.<h4>Methods</h4>We applied our recently published enzyme-linked immunosorbent assays to measure the CSF levels of total α-synuclein, oligomeric α-synuclein, and phosphorylated α-synuclein in dementia with Lewy bodies (n = 42), Alzheimer's disease (n = 39), PD (n = 46), ...[more]

PMID: 30440090

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