In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.
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ABSTRACT:
SUBMITTER: Nash EE
PROVIDER: S-EPMC6519449 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.
Nash Evelyn E EE Henning Tara C TC Pham Cau D CD Pettus Kevin K Sharpe Samera S Kersh Ellen N EN
Diagnostic microbiology and infectious disease 20181110 4
Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous. ...[more]
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