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In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.

ABSTRACT: Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.

SUBMITTER: Nash EE 

PROVIDER: S-EPMC6519449 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.

Nash Evelyn E EE   Henning Tara C TC   Pham Cau D CD   Pettus Kevin K   Sharpe Samera S   Kersh Ellen N EN  

Diagnostic microbiology and infectious disease 20181110 4

Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous. ...[more]

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