Ontology highlight
ABSTRACT:
SUBMITTER: Dobano C
PROVIDER: S-EPMC6520358 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Dobaño Carlota C Sanz Hèctor H Sorgho Hermann H Dosoo David D Mpina Maximilian M Ubillos Itziar I Aguilar Ruth R Ford Tom T Díez-Padrisa Núria N Williams Nana Aba NA Ayestaran Aintzane A Traore Ousmane O Nhabomba Augusto J AJ Jairoce Chenjerai C Waitumbi John J Agnandji Selidji Todagbe ST Kariuki Simon S Abdulla Salim S Aponte John J JJ Mordmüller Benjamin B Asante Kwaku Poku KP Owusu-Agyei Seth S Tinto Halidou H Campo Joseph J JJ Moncunill Gemma G Gyan Ben B Valim Clarissa C Daubenberger Claudia C
Nature communications 20190515 1
RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- ...[more]