Ontology highlight
ABSTRACT:
SUBMITTER: Xiao R
PROVIDER: S-EPMC6520519 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Xiao Run R Mansour Anthony G AG Huang Wei W Chrislip Logan A LA Wilkins Ryan K RK Queen Nicholas J NJ Youssef Youssef Y Mao Hsiaoyin C HC Caligiuri Michael A MA Cao Lei L
Molecular therapy : the journal of the American Society of Gene Therapy 20190216 5
IL-15 is a proinflammatory cytokine that plays an essential role in the development and activation of natural killer (NK) cells. Adipose tissue acts as an endocrine organ that secretes cytokines and is an important reservoir for lymphocytes. We hypothesized that activation of the IL-15 signaling in adipose tissue will activate and expand the NK cell population and control tumor growth. We recently developed an adipocyte-targeting recombinant adeno-associated viral (rAAV) vector with minimal off- ...[more]