A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases.
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ABSTRACT:
SUBMITTER: Florenes VA
PROVIDER: S-EPMC6520638 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases.
Flørenes Vivi Ann VA Flem-Karlsen Karine K McFadden Erin E Bergheim Inger Riise IR Nygaard Vigdis V Nygård Vegard V Farstad Inger Nina IN Øy Geir Frode GF Emilsen Elisabeth E Giller-Fleten Karianne K Ree Anne Hansen AH Flatmark Kjersti K Gullestad Hans Petter HP Hermann Robert R Ryder Truls T Wernhoff Patrik P Mælandsmo Gunhild Mari GM
Translational oncology 20190513 7
Although clinical management of melanoma has changed considerably in recent years, intrinsic treatment resistance remains a severe problem and strategies to design personal treatment regimens are highly warranted. We have applied a three-dimensional (3D) ex vivo drug efficacy assay, exposing disaggregated cells from 38 freshly harvested melanoma lymph node metastases and 21 patient derived xenografts (PDXs) to clinical relevant drugs for 7 days, and examined its potential to evaluate therapy res ...[more]
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Project description: Not available
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