Ontology highlight
ABSTRACT:
SUBMITTER: Florenes VA
PROVIDER: S-EPMC6520638 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Translational oncology 20190513 7
Although clinical management of melanoma has changed considerably in recent years, intrinsic treatment resistance remains a severe problem and strategies to design personal treatment regimens are highly warranted. We have applied a three-dimensional (3D) ex vivo drug efficacy assay, exposing disaggregated cells from 38 freshly harvested melanoma lymph node metastases and 21 patient derived xenografts (PDXs) to clinical relevant drugs for 7 days, and examined its potential to evaluate therapy res ...[more]