Dataset Information

The Association between Salt and Potential Mediators of the Gastric Precancerous Process.

ABSTRACT:

Background

The process by which salt affects the gastric precancerous process has not been adequately studied in humans.

Methods

We investigated the effects of salt on gastric inflammation, epithelial damage, the density of Helicobacter pylori infection, and gastric epithelial cell proliferation, all of which may be mediators between salt and gastric precancerous/cancerous lesions. These potential mediators were measured using gastric biopsies as: (a) the density of polymorphonuclear and mononuclear cells (gastric inflammation), (b) mucus depletion (gastric epithelial damage), and (c) the severity of H. pylori infection. Salt intake was measured with spot urine samples (using urinary sodium/creatinine ratios), self-reported frequency of adding salt to food, and as total added salt.

Results

The average sodium/creatinine ratio (at baseline and post-treatment at five months) was associated with increased epithelial damage over the 12-year follow-up period among those with a greater severity of chronic inflammation and among those with continued H. pylori infection after treatment at five months. This association was stronger when both severe gastric inflammation and H. pylori infection were present at five months (ß: 1.112, 95% CI: 0.377, 1.848).

Conclusion

In humans, salt was associated with an increase in epithelial damage in stomachs with more severe previous H. pylori-induced chronic inflammation.

SUBMITTER: Thapa S

PROVIDER: S-EPMC6520685 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

The Association between Salt and Potential Mediators of the Gastric Precancerous Process.

Thapa Susan S Fischbach Lori A LA Delongchamp Robert R Faramawi Mohammed F MF Orloff Mohammed M

Cancers 20190415 4

<h4>Background</h4>The process by which salt affects the gastric precancerous process has not been adequately studied in humans.<h4>Methods</h4>We investigated the effects of salt on gastric inflammation, epithelial damage, the density of <i>Helicobacter pylori</i> infection, and gastric epithelial cell proliferation, all of which may be mediators between salt and gastric precancerous/cancerous lesions. These potential mediators were measured using gastric biopsies as: (a) the density of polymor ...[more]

PMID: 30991669

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Dataset Information

The Association between Salt and Potential Mediators of the Gastric Precancerous Process.

Background

Methods

Results

Conclusion

Publications

The Association between Salt and Potential Mediators of the Gastric Precancerous Process.

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