Ontology highlight
ABSTRACT:
SUBMITTER: Federico C
PROVIDER: S-EPMC6521283 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Federico Concetta C Owoka Temitayo T Ragusa Denise D Sturiale Valentina V Caponnetto Domenica D Leotta Claudia Giovanna CG Bruno Francesca F Foster Helen A HA Rigamonti Silvia S Giudici Giovanni G Cazzaniga Giovanni G Bridger Joanna M JM Sisu Cristina C Saccone Salvatore S Tosi Sabrina S
Cancers 20190425 4
The radial spatial positioning of individual gene loci within interphase nuclei has been associated with up- and downregulation of their expression. In cancer, the genome organization may become disturbed due to chromosomal abnormalities, such as translocations or deletions, resulting in the repositioning of genes and alteration of gene expression with oncogenic consequences. In this study, we analyzed the nuclear repositioning of <i>HLXB9</i> (also called <i>MNX1</i>), mapping at 7q36.3, in pat ...[more]