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Symptomatic Correlates of Vitamin D Deficiency in First-Episode Psychosis.

ABSTRACT: Previous studies indicate that low levels of vitamin D are associated with increased severity of psychiatric symptoms in chronic multiepisode psychosis (MEP). We aimed to compare vitamin D levels between first-episode psychosis (FEP) and MEP and to investigate the correlations between vitamin D levels and symptoms in FEP patients. The participants were adults aged 18-45 years who presented with affective and non-affective FEP to an early intervention team in Portugal. Depression was assessed using the Beck Depression Inventory, and positive and negative symptoms and general psychopathology were measured with the Positive and Negative Syndrome Scale. Blood samples were analyzed for 25-hydroxyvitamin D (25OHD). Thirty-three patients completed the study in the FEP group and 33 in the MEP group. FEP patients had low levels of 25OHD (18.16 ± 7.48 ng/mL), with no significant differences from MEP patients. Low 25OHD was significantly correlated with high severities of depressive (r=-0.484, p=0.004) and negative (r=-0.480, p=0.005) symptoms as well as general psychopathology (r=-0.569, p=0.001) in FEP patients. Multiple regression revealed an inverse association between general psychopathology and vitamin D level (p=0.027). More investigation of the association of vitamin D and schizophrenia is needed, namely, using a nonpatient control group and trying to clarify possible causality between vitamin D and psychiatric symptoms.

SUBMITTER: Coentre R

PROVIDER: S-EPMC6521317 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Symptomatic Correlates of Vitamin D Deficiency in First-Episode Psychosis.

Coentre Ricardo R Canelas da Silva Inês I

Psychiatry journal 20190502

Previous studies indicate that low levels of vitamin D are associated with increased severity of psychiatric symptoms in chronic multiepisode psychosis (MEP). We aimed to compare vitamin D levels between first-episode psychosis (FEP) and MEP and to investigate the correlations between vitamin D levels and symptoms in FEP patients. The participants were adults aged 18-45 years who presented with affective and non-affective FEP to an early intervention team in Portugal. Depression was assessed usi ...[more]

PMID: 31187033

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Project description:BackgroundThough olfactory deficits are well-documented in schizophrenia, fewer studies have examined olfactory performance profiles across the psychosis spectrum. The current study examined odor identification, discrimination, and detection threshold performance in first-episode psychosis (FEP) patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depression with psychotic features, and other psychotic conditions.MethodFEP patients (n = 97) and healthy adults (n = 98) completed birhinal assessments of odor identification, discrimination, and detection threshold sensitivity for lyral and citralva. Participants also completed measures of anticipatory pleasure, anhedonia, and empathy. Differences in olfactory performances were assessed between FEP patients and controls and within FEP subgroups. Sex-stratified post hoc analyses were employed for a complete analysis of sex differences. Relationships between self-report measures and olfactory scores were also examined.ResultsIndividuals with psychosis had poorer scores across all olfactory measures when compared to the control group. Within the psychosis cohort, patients with schizophrenia-associated psychosis had poorer odor identification, discrimination, and citralva detection threshold scores relative to controls. In schizophrenia patients, greater olfactory disturbance was associated with increased negative symptomatology, greater self-reported anhedonia, and lower self-reported anticipatory pleasure. Patients with mood-associated psychosis performed comparable to controls though men and women in this cohort showed differential olfactory profiles.ConclusionsThese findings indicate that olfactory deficits extend beyond measures of odor identification in FEP with greater deficits observed in schizophrenia-related subgroups of psychosis. Studies examining whether greater olfactory dysfunction confers greater risk for developing schizophrenia relative to other forms of psychosis are warranted.

Dataset Information

Symptomatic Correlates of Vitamin D Deficiency in First-Episode Psychosis.

Publications

Symptomatic Correlates of Vitamin D Deficiency in First-Episode Psychosis.

Similar Datasets

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