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Temporal change in characteristics and outcomes of acute kidney injury on renal replacement therapy in intensive care units: analysis of a nationwide administrative database in Japan, 2007-2016.


ABSTRACT: BACKGROUND:We aimed to examine recent trends in patient characteristics and mortality in patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) and intermittent RRT (IRRT), in intensive care units (ICUs). METHODS:From the Diagnosis Procedure Combination database in Japan during 6?months (July-December) from 2007 to 2016, we identified patients with AKI who received RRT in ICUs. We restricted the study participants to those admitted to hospitals (in which both CRRT and IRRT were available) that participated in the Diagnosis Procedure Combination database for all 10?years. We examined the trends in patient characteristics and mortality overall, by RRT modality, and by main diagnosis category subgroup. Logistic regression was used to adjust for patient characteristics. RESULTS:We identified 51,758 patients starting RRT in 287 hospitals, including 39,471 (76.3%) and 12,287 (23.7%) patients starting CRRT and IRRT. The crude in-hospital mortality declined from 44.9 to 36.1% (P for trend

SUBMITTER: Miyamoto Y 

PROVIDER: S-EPMC6521368 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Temporal change in characteristics and outcomes of acute kidney injury on renal replacement therapy in intensive care units: analysis of a nationwide administrative database in Japan, 2007-2016.

Miyamoto Yoshihisa Y   Iwagami Masao M   Aso Shotaro S   Yasunaga Hideo H   Matsui Hiroki H   Fushimi Kiyohide K   Hamasaki Yoshifumi Y   Nangaku Masaomi M   Doi Kent K  

Critical care (London, England) 20190515 1


<h4>Background</h4>We aimed to examine recent trends in patient characteristics and mortality in patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) and intermittent RRT (IRRT), in intensive care units (ICUs).<h4>Methods</h4>From the Diagnosis Procedure Combination database in Japan during 6 months (July-December) from 2007 to 2016, we identified patients with AKI who received RRT in ICUs. We restricted the study participants to thos  ...[more]

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