Addressing confounding artifacts in reconstruction of gene co-expression networks.
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ABSTRACT:
SUBMITTER: Parsana P
PROVIDER: S-EPMC6521369 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Addressing confounding artifacts in reconstruction of gene co-expression networks.
Parsana Princy P Ruberman Claire C Jaffe Andrew E AE Schatz Michael C MC Battle Alexis A Leek Jeffrey T JT
Genome biology 20190516 1
Gene co-expression networks capture biological relationships between genes and are important tools in predicting gene function and understanding disease mechanisms. We show that technical and biological artifacts in gene expression data confound commonly used network reconstruction algorithms. We demonstrate theoretically, in simulation, and empirically, that principal component correction of gene expression measurements prior to network inference can reduce false discoveries. Using data from th ...[more]
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