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Intra-individual comparison of 68Ga-PSMA-11 and 18F-DCFPyL normal-organ biodistribution.


ABSTRACT: PURPOSE:Detailed data comparing the biodistribution of PSMA radioligands is still scarce, raising concerns regarding the comparability of different compounds. We investigated differences in normal-organ biodistribution and uptake variability between the two most commonly PSMA tracers in clinical use, 68Ga-PSMA-11 and 18F-DCFPyL. METHODS:This retrospective analysis included 34 patients with low tumor burden referred for PET/CT imaging with 68Ga-PSMA-11 and subsequently 18F-DCFPyL. Images were acquired with 4 cross-calibrated PET/CT systems. Volumes of interest were placed on major salivary and lacrimal glands, liver, spleen, duodenum, kidneys, bladder, blood-pool and muscle. Normal-organ biodistribution of both tracers was then quantified as SUVpeak and compared using paired tests, linear regression and Bland-Altman analysis. Between-patient variability was also assessed. Clinical and protocol variables were investigated for possible interference. RESULTS:For both tracers the highest uptake was found in the kidneys and bladder and low background activity was noted across all scans. In the quantitative analysis there was significantly higher uptake of 68Ga-PSMA-11 in the kidneys, spleen and major salivary glands (p?

SUBMITTER: Ferreira G 

PROVIDER: S-EPMC6521415 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Intra-individual comparison of <sup>68</sup>Ga-PSMA-11 and <sup>18</sup>F-DCFPyL normal-organ biodistribution.

Ferreira Gonçalo G   Iravani Amir A   Hofman Michael S MS   Hicks Rodney J RJ  

Cancer imaging : the official publication of the International Cancer Imaging Society 20190515 1


<h4>Purpose</h4>Detailed data comparing the biodistribution of PSMA radioligands is still scarce, raising concerns regarding the comparability of different compounds. We investigated differences in normal-organ biodistribution and uptake variability between the two most commonly PSMA tracers in clinical use, <sup>68</sup>Ga-PSMA-11 and <sup>18</sup>F-DCFPyL.<h4>Methods</h4>This retrospective analysis included 34 patients with low tumor burden referred for PET/CT imaging with <sup>68</sup>Ga-PSMA  ...[more]

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