Dataset Information

Left atrial strain reproducibility using vendor-dependent and vendor-independent software.

ABSTRACT: BACKGROUND:Two-dimensional speckle-tracking echocardiography (2D-STE) enables objective assessment of left atrial (LA) deformation through the analysis of myocardial strain, which can be measured by different speckle-tracking software. The aim of this study was to compare the consistency of 3 different commercially available software, which include vendor-specific software for measuring left ventricle (VSSLV), vendor-independent software packages for measuring LV strain (VISLV) and vendor-independent software packages for measuring LA strain (VISLA). METHODS:Sixty-four subjects (mean age: 44?±?16?years, 50% males) underwent conventional echocardiograms using a GE Vivid 9 (GE Ultrasound, Horten, Norway) cardiac ultrasound system. Standard apical 4 and 2 chamber views of the left atrium were obtained in each subject with a frame-rate range of 40-71 frames/s. LA strain during the contraction phase (Sct), conduit phase (Scd), reservoir phase (Sr?=?Sct?+?Scd) were analyzed by 2 independent observers and 3 different software. RESULTS:Sct, Scd, Sr were, respectively, -?11.26?±?2.45%, -?16.77?±?7.06%, and 28.03?±?7.58% with VSSLV, -?14.77?±?3.59%, -?23.17?±?10.33%, and 38.23?±?10.99% with VISLV, and?-?14.80?±?3.88%, -?23.94?±?10.48%, and 38.73?±?11.56% when VISLA was used. A comparison of strain measurements between VSSLV and VIS (VISLV and VISLA) showed VIS had significantly smaller mean differences and narrower limits of agreement. Similar results were observed in the coefficient of variation (CV) for measurements between VSSLV and VIS (VISLV and VISLA). Comparison of the intra-class correlation coefficients (ICCs) indicated that measurement reliability was weaker with VSSLV (ICC??0.9). For intra-observer ICCs, VISLA?>?VSSLV?=?VISLV. For inter-observer ICCs, VSSLV?>?VISLA?>?VISLV. CONCLUSIONS:Software measurement results of LA strain vary considerably. We recommended not measuring LA strain across vendor platforms.

SUBMITTER: Wang Y

PROVIDER: S-EPMC6521472 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Left atrial strain reproducibility using vendor-dependent and vendor-independent software.

Wang Yu Y Li Zhilian Z Fei Hongwen H Yu Yongsen Y Ren Siqi S Lin Qiongwen Q Li Hezhi H Tang Yongwen Y Hou Yuezheng Y Li Mingqi M

Cardiovascular ultrasound 20190515 1

<h4>Background</h4>Two-dimensional speckle-tracking echocardiography (2D-STE) enables objective assessment of left atrial (LA) deformation through the analysis of myocardial strain, which can be measured by different speckle-tracking software. The aim of this study was to compare the consistency of 3 different commercially available software, which include vendor-specific software for measuring left ventricle (VSS<sub>LV</sub>), vendor-independent software packages for measuring LV strain (VIS<s ...[more]

PMID: 31092263

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Project description:ObjectivesTo determine the test-retest reproducibility and observer variability of CMR-derived LA function, using (i) LA strain (LAS) and strain rate (LASR), and (ii) LA volumes (LAV) and emptying fraction (LAEF).MethodsSixty participants with and without cardiovascular disease (aortic stenosis (AS) (n = 16), type 2 diabetes (T2D) (n = 28), end-stage renal disease on haemodialysis (n = 10) and healthy volunteers (n = 6)) underwent two separate CMR scans 7-14 days apart. LAS and LASR, corresponding to LA reservoir, conduit and contractile booster-pump function, were assessed using Feature Tracking software (QStrain v2.0). LAEF was calculated using the biplane area length method (QMass v8.1). Both were assessed using 4- and 2-chamber long-axis standard steady-state free precession cine images, and average values were calculated. Intra- and inter-observer variabilities were assessed in 10 randomly selected participants.ResultsThe test-retest reproducibility was moderate to poor for all strain and strain rate parameters. Overall, strain and strain rate corresponding to reservoir phase (LAS_r, LASR_r) were the most reproducible, yielding the smallest coefficient of variance (CoV) (29.9% for LAS_r, 28.9% for LASR_r). The test-retest reproducibility for LAVs and LAEF was good: LAVmax CoV = 19.6% ICC = 0.89, LAVmin CoV = 27.0% ICC = 0.89 and total LAEF CoV = 15.6% ICC = 0.78. The inter- and intra-observer variabilities were good for all parameters except for conduit function.ConclusionThe test-retest reproducibility of LA strain and strain rate assessment by CMR utilising Feature Tracking is moderate to poor across disease states, whereas LA volume and emptying fraction are more reproducible on CMR. Further improvements in LA strain quantification are needed before widespread clinical application.Key points• LA strain and strain rate assessment using Feature Tracking on CMR has moderate to poor test-retest reproducibility across disease states. • The test-retest reproducibility for the biplane method of assessing LA function is better than strain assessment, with lower coefficient of variances and narrower limits of agreement on Bland-Altman plots. • Biplane LA volumetric measurement also has better intra- and inter-observer variability compared to strain assessment.

Dataset Information

Left atrial strain reproducibility using vendor-dependent and vendor-independent software.

Publications

Left atrial strain reproducibility using vendor-dependent and vendor-independent software.

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