Dataset Information

Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review.

ABSTRACT:

Background/aims

Despite the wide use of acupuncture for the management of visceral pain and the growing interest in the pathophysiology of visceral pain, there is no conclusive elucidation of the mechanisms behind the effects of acupuncture on visceral pain. This systematic review aims to provide an integrative understanding of the treatment mechanism of acupuncture for visceral pain.

Methods

Electronic and hand searches were conducted to identify studies that involved visceral pain and acupuncture.

Results

We retrieved 192 articles, out of which 46 studies were included in our review. The results of our review demonstrated that visceral pain behaviors were significantly alleviated in response to acupuncture treatment in groups treated with this intervention compared to in sham acupuncture or no-treatment groups. Changes in the concentrations of ?-endorphin, epinephrine, cortisol, and prostaglandin E2 in plasma, the levels of c-Fos, substance P, corticotropin-releasing hormone, P2X3, acetylcholinesterase (AchE), N-methyl-D-aspartate (NMDA) receptors, and serotonin in the gut/spinal cord, and the neuronal activity of the thalamus were associated with acupuncture treatment in visceral pain.

Conclusions

Acupuncture reduced visceral pain behavior and induced significant changes in neuronal activity as well as in the levels of pain/inflammation-related cytokines and neurotransmitters in the brain-gut axis. Further researches on the thalamus and on a standard animal model are warranted to improve our knowledge on the mechanism of acupuncture that facilitates visceral pain modulation.

SUBMITTER: Lee IS

PROVIDER: S-EPMC6521529 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review.

Lee In-Seon IS Cheon Soyeon S Park Ji-Yeun JY

Evidence-based complementary and alternative medicine : eCAM 20190502

<h4>Background/aims</h4>Despite the wide use of acupuncture for the management of visceral pain and the growing interest in the pathophysiology of visceral pain, there is no conclusive elucidation of the mechanisms behind the effects of acupuncture on visceral pain. This systematic review aims to provide an integrative understanding of the treatment mechanism of acupuncture for visceral pain.<h4>Methods</h4>Electronic and hand searches were conducted to identify studies that involved visceral pa ...[more]

PMID: 31186654

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Project description:IntroductionThis review aims to evaluate the effectiveness and safety of acupuncture for patients with postoperative pain after laparoscopic surgery.Methods and analysisWe will search the following databases from their inception to October 2014: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Allied and Complementary Medicine Database (AMED), three Chinese databases (China National Knowledge Infrastructure (CNKI), the Chongqing VIP Chinese Science and Technology Periodical Database (VIP) and the Wanfang database), one Japanese database (Japan Science and Technology Information Aggregator, Electronic (J-STAGE)) and eight Korean databases (Korean Association of Medical Journal Edition, Korean Medical Database, Korean Studies Information Service System, National Discovery for Science Leaders, Database Periodical Information Academic, Korean National Assembly Digital Library, Oriental Medicine Advanced Searching Integrated System and Korean Traditional Knowledge Portal). All randomised controlled trials of acupuncture for postoperative pain after laparoscopic surgery will be considered for inclusion. The risk of bias and reporting quality will be assessed using the Cochrane risk of bias tool, the Consolidated Standards of Reporting Trials (CONSORT) and the revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA). The risk ratio for dichotomous data and mean difference or standard mean difference for continuous data will be calculated with 95% CIs.DisseminationThe results of this review will be disseminated through peer-reviewed publication or conference presentation. Our findings will summarise the current evidence of acupuncture to treat postoperative pain after laparoscopic surgery, and may provide important guidance for acupuncture usage after laparoscopic surgery for clinicians and patients.Trial registration numberPROSPERO 2014: CRD42014010825.

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Dataset Information

Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review.

Background/aims

Methods

Results

Conclusions

Publications

Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review.

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