Ontology highlight
ABSTRACT:
SUBMITTER: Rane HS
PROVIDER: S-EPMC6521590 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Rane Hallie S HS Hayek Summer R SR Frye Jillian E JE Abeyta Esteban L EL Bernardo Stella M SM Parra Karlett J KJ Lee Samuel A SA
Frontiers in microbiology 20190509
<i>Candida albicans</i> occupies diverse ecological niches within the host and must tolerate a wide range of environmental pH. The plasma membrane H<sup>+</sup>-ATPase Pma1p is the major regulator of cytosolic pH in fungi. Pma1p extrudes protons from the cytosol to maintain neutral-to-alkaline pH and is a potential drug target due to its essentiality and fungal specificity. We characterized mutants in which one allele of <i>PMA1</i> has been deleted and the other truncated by 18-38 amino acids. ...[more]