Ontology highlight
ABSTRACT:
SUBMITTER: Thibord F
PROVIDER: S-EPMC6521604 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20190228 6
Next-generation sequencing is an increasingly popular and efficient approach to characterize the full set of microRNAs (miRNAs) present in human biosamples. MiRNAs' detection and quantification still remain a challenge as they can undergo different posttranscriptional modifications and might harbor genetic variations (polymiRs) that may impact on the alignment step. We present a novel algorithm, OPTIMIR, that incorporates biological knowledge on miRNA editing and genome-wide genotype data availa ...[more]