Ontology highlight
ABSTRACT:
SUBMITTER: Neginskaya MA
PROVIDER: S-EPMC6521848 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Neginskaya Maria A MA Solesio Maria E ME Berezhnaya Elena V EV Amodeo Giuseppe F GF Mnatsakanyan Nelli N Jonas Elizabeth A EA Pavlov Evgeny V EV
Cell reports 20190101 1
Permeability transition (PT) is an increase in mitochondrial inner membrane permeability that can lead to a disruption of mitochondrial function and cell death. PT is responsible for tissue damage in stroke and myocardial infarction. It is caused by the opening of a large conductance (∼1.5 nS) channel, the mitochondrial PT pore (mPTP). We directly tested the role of the c-subunit of ATP synthase in mPTP formation by measuring channel activity in c-subunit knockout mitochondria. We found that the ...[more]