Ontology highlight
ABSTRACT:
SUBMITTER: Lin DL
PROVIDER: S-EPMC6521869 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Lin David L DL Inoue Takamasa T Chen Yu-Jie YJ Chang Aaron A Tsai Billy B Tai Andrew W AW
Cell reports 20190501 6
Although flaviviruses co-opt the function of the host endoplasmic reticulum (ER) membrane protein complex (EMC) during infection, a mechanistic explanation for this observation remains unclear. Here, we show that the EMC promotes biogenesis of dengue virus (DENV) and Zika virus (ZIKV) non-structural multi-pass transmembrane proteins NS4A and NS4B, which are necessary for viral replication. The EMC binds to NS4B and colocalizes with the DENV replication organelle. Mapping analysis reveals that th ...[more]