Ontology highlight
ABSTRACT:
SUBMITTER: Zapata HJ
PROVIDER: S-EPMC6521921 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Zapata Heidi J HJ Van Ness Peter H PH Avey Stefan S Siconolfi Barbara B Allore Heather G HG Tsang Sui S Wilson Jean J Barakat Lydia L Mohanty Subhasis S Shaw Albert C AC
The journals of gerontology. Series A, Biological sciences and medical sciences 20190501 6
Both aging and HIV infection are associated with an enhanced pro-inflammatory environment that contributes to impaired immune responses and is mediated in part by innate immune pattern-recognition receptors. MINCLE is a C-type lectin receptor that recognizes trehalose-6,6'-dimycolate or "cord factor," the most abundant glycolipid in Mycobacterium tuberculosis. Here, we evaluated MINCLE function in monocytes in a cohort of HIV-infected and uninfected young (21-35 years) and older adults (≥60 year ...[more]