Ontology highlight
ABSTRACT:
SUBMITTER: Passos da Silva D
PROVIDER: S-EPMC6522473 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Passos da Silva Daniel D Matwichuk Michael L ML Townsend Delaney O DO Reichhardt Courtney C Lamba Doriano D Wozniak Daniel J DJ Parsek Matthew R MR
Nature communications 20190516 1
Pseudomonas aeruginosa biofilms are composed of exopolysaccharides (EPS), exogenous DNA, and proteins that hold these communities together. P. aeruginosa produces lectins LecA and LecB, which possess affinities towards sugars found in matrix EPS and mediate adherence of P. aeruginosa to target host cells. Here, we demonstrate that LecB binds to Psl, a key matrix EPS, and this leads to increased retention of both cells and EPS in a growing biofilm. This interaction is predicted to occur between t ...[more]