Ontology highlight
ABSTRACT:
SUBMITTER: Guo Z
PROVIDER: S-EPMC6522541 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Guo Zhe Z Song Jing J Hao Junxia J Zhao Hui H Du Xiaohui X Li Encheng E Kuang Yanbin Y Yang Fuquan F Wang Wei W Deng Jiong J Wang Qi Q
Cell death & disease 20190516 6
The mechanism by which tumor-associated macrophages (TAMs) affect cancer progression is not fully understood. This study developed a microfluidic-based co-culture device to mimic the tumor microenvironment to assess TAM effects on invasion and metastasis in NSCLC. The results showed lung carcinoma cells could cause macrophages to show the M2 (a TAM-like) phenotype, and these M2 macrophages promoted lung cancer cell EMT and invasion. Proteomic analysis by the iTRAQ quantitation strategy and GO on ...[more]