Ontology highlight
ABSTRACT:
SUBMITTER: Soliman AM
PROVIDER: S-EPMC6522976 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Soliman Aiten M AM Alqahtani Ali S AS Ghorab Mostafa M
Journal of enzyme inhibition and medicinal chemistry 20191201 1
A series of sulphonamide benzoquinazolinones 5-18 was synthesized and evaluated for cytotoxic activity against MDA-MB-231 cell line. The compounds showed IC<sub>50</sub> ranging from 0.26 to 161.49 µM. The promising compounds were evaluated for their inhibitory profile against epidermal growth factor (EGFR) and HER2 enzymes. Compound 10 showed more potent activity on both EGFR and HER2 than erlotinib (IC<sub>50</sub> 3.90 and 5.40 µM versus 6.21 and 9.42 µM). The pro-apoptotic activity of 10 was ...[more]