Targeting Hedgehog (Hh) Pathway for the Acute Myeloid Leukemia Treatment.
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ABSTRACT:
SUBMITTER: Terao T
PROVIDER: S-EPMC6523210 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Targeting Hedgehog (Hh) Pathway for the Acute Myeloid Leukemia Treatment.
Terao Toshiki T Minami Yosuke Y
Cells 20190403 4
The Hedgehog (Hh) pathway, containing the Patched (PTCH) and Smoothened (SMO) multitransmembrane proteins, is the main regulator of vertebrate embryonic development. A non-canonical Hh pathway was recently observed in numerous types of solid cancers and hematological malignancies. Although acute myeloid leukemia (AML) is a common and lethal myeloid malignancy, the chemotherapy for AML has not changed in the last three decades. The Hh pathway and other intracellular signaling pathways are importa ...[more]
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