Ontology highlight
ABSTRACT:
SUBMITTER: Stepanic V
PROVIDER: S-EPMC6523444 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Stepanić Višnja V Matijašić Mario M Horvat Tea T Verbanac Donatella D Kučerová-Chlupáčová Marta M Saso Luciano L Žarković Neven N
Antioxidants (Basel, Switzerland) 20190405 4
Chalcones are polyphenolic secondary metabolites of plants, many of which have antioxidant activity. Herein, a set of 26 synthetic chalcone derivatives with alkyl substituted pyrazine heterocycle A and four types of the monophenolic ring B, were evaluated for the potential radical scavenging and antioxidant cellular capacity influencing the growth of cells exposed to H₂O₂. Before that, compounds were screened for cytotoxicity on THP-1 and HepG2 cell lines. Most of them were not cytotoxic in an o ...[more]