Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics.

ABSTRACT: Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine drug resistance and provide treatment guidelines that include personalized targeted therapies. The Hedgehog (Hh) signaling pathway plays an essential role in embryonic development, tissue regeneration, and stem cell renewal. Several lines of evidence endorse the important role of canonical and non-canonical Hh signaling in BC. In this comprehensive review we discuss the role of Hh signaling in breast development and homeostasis and its contribution to tumorigenesis and progression of different subtypes of BC. We also examine the efficacy of agents targeting different

SUBMITTER: Riobo-Del Galdo NA 

PROVIDER: S-EPMC6523618 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature