Ontology highlight
ABSTRACT:
SUBMITTER: Lameirinhas A
PROVIDER: S-EPMC6523766 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lameirinhas Ana A Miranda-Gonçalves Vera V Henrique Rui R Jerónimo Carmen C
Genes 20190402 4
Renal cell carcinoma (RCC) is the most common malignancy affecting the kidney. Current therapies are mostly curative for localized disease, but do not completely preclude recurrence and metastization. Thus, it is imperative to develop new therapeutic strategies based on RCC biological properties. Presently, metabolic reprograming and epigenetic alterations are recognized cancer hallmarks and their interactions are still in its infancy concerning RCC. In this review, we explore RCC biology, highl ...[more]