Dermatopontin in Skeletal Muscle Extracellular Matrix Regulates Myogenesis.
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ABSTRACT:
SUBMITTER: Kim T
PROVIDER: S-EPMC6523808 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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Dermatopontin in Skeletal Muscle Extracellular Matrix Regulates Myogenesis.
Kim Taeyeon T Ahmad Khurshid K Shaikh Sibhghatulla S Jan Arif Tasleem AT Seo Myung-Gi MG Lee Eun Ju EJ Choi Inho I
Cells 20190409 4
Dermatopontin (DPT) is an extensively distributed non-collagenous component of the extracellular matrix predominantly found in the dermis of the skin, and consequently expressed in several tissues. In this study, we explored the role of DPT in myogenesis and perceived that it enhances the cell adhesion, reduces the cell proliferation and promotes the myoblast differentiation in C2C12 cells. Our results reveal an inhibitory effect with fibronectin (FN) in myoblast differentiation. We also observe ...[more]
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