Out-of-Plane Aptamer Functionalization of RNA Three-Helix Tiles.
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ABSTRACT:
SUBMITTER: Chopra A
PROVIDER: S-EPMC6523889 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Out-of-Plane Aptamer Functionalization of RNA Three-Helix Tiles.
Chopra Aradhana A Sagredo Sandra S Grossi Guido G Andersen Ebbe S ES Simmel Friedrich C FC
Nanomaterials (Basel, Switzerland) 20190402 4
Co-transcriptionally folding RNA nanostructures have great potential as biomolecular scaffolds, which can be used to organize small molecules or proteins into spatially ordered assemblies. Here, we develop an RNA tile composed of three parallel RNA double helices, which can associate into small hexagonal assemblies via kissing loop interactions between its two outer helices. The inner RNA helix is modified with an RNA motif found in the internal ribosome entry site (IRES) of the hepatitis C viru ...[more]
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