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Predictors and reproducibility of exercise-induced bronchoconstriction in cold air.


ABSTRACT: BACKGROUND:Physical activity is an important part of life, and hence exercise-induced bronchoconstriction (EIB) can reduce the quality of life. A standardized test is needed to diagnose EIB. The American Thoracic Society (ATS) guidelines recommend an exercise challenge in combination with dry air. We investigated the feasibility of a new, ATS guidelines conform exercise challenge in a cold chamber (ECC) to detect EIB. The aim of this study was to investigate the surrogate marker reaction to methacholine, ECC and exercise challenge in ambient temperature for the prediction of a positive reaction and to re-evaluate the reproducibility of the response to an ECC. METHODS:Seventy-eight subjects aged 6 to 40?years with suspected EIB were recruited for the study. The subjects performed one methacholine challenge, two ECCs, and one exercise challenge at an ambient temperature. To define the sensitivity and specificity of the predictor, a receiver-operating characteristic curve was plotted. The repeatability was evaluated using the method described by Bland and Altman (95% Limits of agreement). RESULTS:The following cut-off values showed the best combination of sensitivity and specificity: the provocation dose causing a 20% decrease in the forced expiratory volume in 1?s (PD20FEV1) of methacholine: 1.36?mg (AUC 0.69, p?

SUBMITTER: Dreßler M 

PROVIDER: S-EPMC6524332 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Predictors and reproducibility of exercise-induced bronchoconstriction in cold air.

Dreßler Melanie M   Friedrich Theresa T   Lasowski Natali N   Herrmann Eva E   Zielen Stefan S   Schulze Johannes J  

BMC pulmonary medicine 20190516 1


<h4>Background</h4>Physical activity is an important part of life, and hence exercise-induced bronchoconstriction (EIB) can reduce the quality of life. A standardized test is needed to diagnose EIB. The American Thoracic Society (ATS) guidelines recommend an exercise challenge in combination with dry air. We investigated the feasibility of a new, ATS guidelines conform exercise challenge in a cold chamber (ECC) to detect EIB. The aim of this study was to investigate the surrogate marker reaction  ...[more]

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