Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC6524650 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Liu Qi Q Sinnen Brooke L BL Boxer Emma E EE Schneider Martin W MW Grybko Michael J MJ Buchta William C WC Gibson Emily S ES Wysoczynski Christina L CL Ford Christopher P CP Gottschalk Alexander A Aoto Jason J Tucker Chandra L CL Kennedy Matthew J MJ
Neuron 20190128 5
Regulated secretion is critical for diverse biological processes ranging from immune and endocrine signaling to synaptic transmission. Botulinum and tetanus neurotoxins, which specifically proteolyze vesicle fusion proteins involved in regulated secretion, have been widely used as experimental tools to block these processes. Genetic expression of these toxins in the nervous system has been a powerful approach for disrupting neurotransmitter release within defined circuitry, but their current uti ...[more]