Chemotherapy Alters the Phylogenetic Molecular Ecological Networks of Intestinal Microbial Communities.

ABSTRACT: Intestinal microbiota is now widely known to play key roles in nutritional uptake, metabolism, and regulation of human immune responses. There are multiple studies assessing intestinal microbiota changes in response to chemotherapy. In this study, microbial phylogenetic molecular ecological networks (pMENs) were firstly used to study the effects of chemotherapy on the intestinal microbiota of colorectal cancer (CRC) patients. Based on the random network model, we demonstrated that overall network structures and properties were significantly changed by chemotherapy, especially in average path length, average clustering coefficient, average harmonic geodesic distance and modularity (P < 0.05). The taxa in the module tended to co-exclude rather than co-occur in CRC patient networks, in

SUBMITTER: Cong J 

PROVIDER: S-EPMC6524687 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature