Ontology highlight
ABSTRACT:
SUBMITTER: Ferreiros A
PROVIDER: S-EPMC6524732 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Ferreirós Alba A Pedrosa Pablo P Da Silva-Álvarez Sabela S Triana-Martínez Francisco F Vilas Jéssica M JM Picallos-Rabina Pilar P González Patricia P Gómez María M Li Han H García-Caballero Tomás T González-Barcia Miguel M Vidal Anxo A Collado Manuel M
Stem cell reports 20190502 5
Induction of pluripotency in somatic cells with defined genetic factors has been successfully used to investigate the mechanisms of disease initiation and progression. Cellular reprogramming and oncogenic transformation share common features; both involve undergoing a dramatic change in cell identity, and immortalization is a key step for cancer progression that enhances reprogramming. However, there are very few examples of complete successful reprogramming of tumor cells. Here we address the e ...[more]