Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC6524754 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Kim Hyosung H Xu Ranjie R Padmashri Ragunathan R Dunaevsky Anna A Liu Ying Y Dreyfus Cheryl F CF Jiang Peng P
Stem cell reports 20190501 5
The process of oligodendrogenesis has been relatively well delineated in the rodent brain. However, it remains unknown whether analogous developmental processes are manifested in the human brain. Here we report oligodendrogenesis in forebrain organoids, generated by using OLIG2-GFP knockin human pluripotent stem cell (hPSC) reporter lines. OLIG2/GFP exhibits distinct temporal expression patterns in ventral forebrain organoids (VFOs) versus dorsal forebrain organoids (DFOs). Interestingly, oligod ...[more]