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Development and translation of novel therapeutics targeting tumor-associated macrophages.

ABSTRACT: Tumor-associated macrophages (TAMs) regulate an array of tumor functions and have critical roles in both the progression and the eradication of cancer. Numerous therapies targeting TAMs are under development in cancer and many have demonstrated success at the preclinical and clinical levels. Most of these therapies fall within 3 main categories: systemic depletion of TAMs, inhibition of TAM recruitment and polarization, and promoting the antitumor functions of TAMs. In this article, the rationale behind these various therapies and approaches is reviewed along with supporting preclinical and clinical data.

SUBMITTER: Kosoff D

PROVIDER: S-EPMC6525088 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Development and translation of novel therapeutics targeting tumor-associated macrophages.

Kosoff David D Lang Joshua M JM

Urologic oncology 20181117 8

Tumor-associated macrophages (TAMs) regulate an array of tumor functions and have critical roles in both the progression and the eradication of cancer. Numerous therapies targeting TAMs are under development in cancer and many have demonstrated success at the preclinical and clinical levels. Most of these therapies fall within 3 main categories: systemic depletion of TAMs, inhibition of TAM recruitment and polarization, and promoting the antitumor functions of TAMs. In this article, the rational ...[more]

PMID: 30458979

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