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Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion.

ABSTRACT: HER2/ErbB2 activation turns on transcriptional processes that induce local invasion and lead to systemic metastasis. The early transcriptional changes needed for ErbB2-induced invasion are poorly understood. Here, we link ErbB2 activation to invasion via ErbB2-induced, SUMO-directed phosphorylation of a single serine residue, S27, of the transcription factor myeloid zinc finger-1 (MZF1). Utilizing an antibody against MZF1-pS27, we show that the phosphorylation of S27 correlates significantly (p?

SUBMITTER: Brix DM

PROVIDER: S-EPMC6525100 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion.

Brix Ditte Marie DM Tvingsholm Siri Amanda SA Hansen Malene Bredahl MB Clemmensen Knut Bundgaard KB Ohman Tiina T Siino Valentina V Lambrughi Matteo M Hansen Klaus K Puustinen Pietri P Gromova Irina I James Peter P Papaleo Elena E Varjosalo Markku M Moreira José J Jäättelä Marja M Kallunki Tuula T

Oncogene 20190108 17

HER2/ErbB2 activation turns on transcriptional processes that induce local invasion and lead to systemic metastasis. The early transcriptional changes needed for ErbB2-induced invasion are poorly understood. Here, we link ErbB2 activation to invasion via ErbB2-induced, SUMO-directed phosphorylation of a single serine residue, S27, of the transcription factor myeloid zinc finger-1 (MZF1). Utilizing an antibody against MZF1-pS27, we show that the phosphorylation of S27 correlates significantly (p ...[more]

PMID: 30622337

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