Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC6525236 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Yang Fan F Hu Huili H Liu Yuanyuan Y Shao Ming M Shao Changshun C Gong Yaoqin Y
Cell death & disease 20190517 6
CUL4A and CUL4B are closely related members in Cullin family and can each assemble a Cullin-RING E3 ligase complex (Cullin-RING Ligase 4A or 4B, CRL4A, or CRL4B) and participate in a variety of biological processes. Previously we showed that zebrafish cul4a, but not cul4b, is essential for cardiac and pectoral fin development. Here, we have identified cul4a as a crucial regulator of primitive erythropoiesis in zebrafish embryonic development. Depletion of cul4a resulted in a striking reduction o ...[more]