Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis.

ABSTRACT: BACKGROUND:We retrieved different reports containing different genetic effects of -?1082 A/G, -?819?T/C, and?-?592 A/C polymorphisms within the IL-10 (interleukin-10) gene on the susceptibility to clinical atopic dermatitis. METHODS:Herein, we conducted a meta-analysis to comprehensively assess such a genetic relationship after collecting the available published evidence. STATA 12.0 software was used for the statistical analysis under the allelic, homozygotic, heterozygotic, dominant, recessive and carrier genetic models. RESULTS:By retrieving and screening database literature, a total of 16 eligible case-control studies were finally selected. For the IL-10 -1082 A/G polymorphism, we did not detect a significant difference between atopic dermatitis cases and population-based controls in the overall meta-analysis under the genetic models of allele G vs. A (P?=?0.540), GG vs. AA (P?=?0.853), AG vs AA (P?=?0.265), AG?+?GG vs AA (P?=?0.221), GG vs AA+AG (P?=?0.540) and carrier G vs. A (P?=?0.643). Moreover, a statistically non-significant association was observed in the most subgroup meta-analyses by the factors of ethnicity, country and Hardy-Weinberg equilibrium. Likewise, the negative results were detected for the synthetic analysis of IL-10 -819?T/C and?-?592 C/A polymorphisms. CONCLUSION:The current evidence does not support a strong genetic relationship between IL-10 -1082 A/G, -?819?T/C and?-?592 A/C polymorphisms and the susceptibility to atopic dermatitis.

SUBMITTER: Qi Y 

PROVIDER: S-EPMC6525399 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature