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Regulatory T cells limit unconventional memory to preserve the capacity to mount protective CD8 memory responses to pathogens.

ABSTRACT: Immunological memory exists so that following infection an expanded population of pathogen-specific lymphocytes can rapidly and efficiently control infection in the case of reexposure. However, in the case of CD8+ T lymphocytes, a population of unconventional CD44+CD122+ virtual memory T cells (T_VM) has been described that possesses many, though not all, features of "true memory" T cells, without the requirement of first encountering cognate antigen. Here, we demonstrate a role for regulatory T cell-mediated restraint of T_VM at least in part through limiting IL-15 trans-presentation by CD11b+ dendritic cells. Further, we show that keeping T_VM in check ensures development of functional, antigen-specific "true" memory phenotype CD8+ T cells that can assist in pathogen control upon reexposure.

SUBMITTER: Da Costa AS

PROVIDER: S-EPMC6525503 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Regulatory T cells limit unconventional memory to preserve the capacity to mount protective CD8 memory responses to pathogens.

Da Costa Andreia S AS Graham Jessica B JB Swarts Jessica L JL Lund Jennifer M JM

Proceedings of the National Academy of Sciences of the United States of America 20190429 20

Immunological memory exists so that following infection an expanded population of pathogen-specific lymphocytes can rapidly and efficiently control infection in the case of reexposure. However, in the case of CD8+ T lymphocytes, a population of unconventional CD44+CD122+ virtual memory T cells (T<sub>VM</sub>) has been described that possesses many, though not all, features of "true memory" T cells, without the requirement of first encountering cognate antigen. Here, we demonstrate a role for re ...[more]

PMID: 31036644

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