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Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines.

ABSTRACT: The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Q?. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model.

SUBMITTER: Huo CX

PROVIDER: S-EPMC6525565 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines.

Huo Chang-Xin CX Dhara Debashis D Baliban Scott M SM Tahmasebi Nick Setare S Tan Zibin Z Simon Raphael R Misra Anup Kumar AK Huang Xuefei X

Chemical communications (Cambridge, England) 20190401 31

The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model. ...[more]

PMID: 30924468

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